Table 3. Univariate and multivariate analyses of miR-223-3p and SLC4A4 mRNA level and patient disease–free survival.

	Univariate analysis			Multivariate analysisc
Variable	HRa	95%CIb	P	HRa	95% CIb	P
Disease–free survival (n = 407)
Age (years)
>60 (n = 184)	1.458	1.020-2.083	0.038*
≤60 (n = 223)
Sex
Male (n = 272)	1.345	0.904-2.001	0.143
Female (n = 135)
T stage
T3 or T4 (n = 140)	4.333	2.989-6.280	0.000*	2.116	1.387-3.226	0.001*
T1 or T2 (n = 267)
N stage
N1 (n = 12)	5.848	2.935-11.656	0.000*	2.850	1.396-5.818	0.004*
N0 or NX (n =395)
M stage
M1 (n = 52)	8.124	5.579-11.831	0.000*	4.901	3.222-7.455	0.000*
M0 or MX (n = 355)
Grade
G3 or G4 (n = 210)	3.205	2.120-4.844	0.000*	2.195	1.425-3.382	0.000*
G1 or G2 (n = 197)
miR-223-3p
High (n = 250)	1.342	0.938-1.921	0.108
Low (n = 250)
SLC4A4
High (n = 250)	0.586	0.407-0.844	0.004*	0.607	0.419-0.880	0.008*
Low (n = 250)

^aHazard ratio, estimated from Cox proportional hazard regression model.

^bLower and upper confidence interval of the estimated HR.

^cMultivariate models were adjusted for T, N, M classification, age and sex.

HR hazard ratio, CI confidential interval, T stages Tumor stage, N stage lymphatic metastasis, M stage distant metastasis