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. 2019 Jan 17;11(2):401–422. doi: 10.18632/aging.101748

Table 1. Expression changes of cell cycle-, chromatin remodeling-, neuronal development-related genes regulated by 3,4,5-tricaffeoylquinic acid (TCQA).

Gene title Gene symbol Fold change Function Category
Ceramide Kinase Like CERKL 1.51 cell cycle, activation of protein kinase C Cell cycle
Translocated Promoter Region, Nuclear Basket Protein TPR 1.45 negative regulation of mitosis, cell cycle checkpoint
Structural Maintenance Of Chromosomes 4 SMC4 1.42 cell cycle, chromosome organization
Remodeling And Spacing Factor 1 RSF1 1.35 cell cycle, histone binding,
Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 DYRK2 1.32 activation of p53, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth.
Replication Timing Regulatory Factor 1 RIF1 1.29 postsynaptic density, actin projection, Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint)
Plasminogen-related protein B PLGLB 1.28 cell cycle arrest
Transforming Acidic Coiled-Coil Containing Protein 3 TACC3 -1.22 cell cycle, cell proliferation in forebrain, protein transport, protein localization,
Anaphase Promoting Complex Subunit 7 ANAPC7 -1.24 Cell cycle (M phase), protein modification,
DNA Replication And Sister Chromatid Cohesion 1 DSCC1 -1.24 cell cycle (M phase), DNA replication
Polo Like Kinase 4 PLK4 -1.24 cell cycle, regulation of centrosome duplication, protein kinase activity
Minichromosome Maintenance Complex Component 4 MCM4 -1.26 DNA replication, Cell cycle
HUS1 Checkpoint Clamp Component HUS1 -1.30 Cell cycle, DNA repair, G1/S transition,
SET domain containing (lysine methyltransferase) 8 SETD8 -1.31 Cell cycle (M phase), chromatin modification, negative regulation of gene and protein expression, methyl transferase
alpha-thalassemia ATRX 1.71 DNA repair, DNA methylation, zinc ion binding, forebrain development Chromatin remodeling
Bromodomain Adjacent To Zinc Finger Domain 1A BAZ1A 1.44 transcription, zinc ion binding, chromatin remodeling
Lysine-specific demethylase 5A KDM5A 1.37 chromatin organization, oxidation reduction, zinc ion binding
Nuclear Receptor Corepressor 1 NCOR1 1.36 chromatin organization, negative regulation of transcription from RNA polymerase II promoter, negative regulation of JNK cascade, promotes histone deacetylation
Bromodomain Adjacent To Zinc Finger Domain 1B BAZ1B 1.31 chromatin organization, chromatin remodeling, chromatin regulation / acetylation
Potassium Voltage-Gated Channel Subfamily Q Member 1 KCNQ1 1.30 chromatin regulation
SKI proto-oncogene SKI 1.30 negative regulation of transcription from RNA polymerase II promoter, negative regulation of activin receptor signaling pathway, TGF-beta signaling
GLIS Family Zinc Finger 3 GLIS3 1.28 chromatin organization, zinc ion binding
AT-rich interactive domain-containing protein 2 ARID2 1.28 Required for the stability of the SWI/SNF chromatin remodeling complex
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) RUNX1T1 1.28 chromatin organization, zinc ion binding, binding to histone deacetylases and transcription factors
G Protein Subunit Beta 4 GNB4 1.28 negative regulation of transcription from RNA polymerase II promoter
Chromodomain Helicase DNA Binding Protein 4 CHD4 1.25 chromatin organization, SNF2-related, remodeling of chromatin by deacetylating histones
Myb Like, SWIRM And MPN Domains 1 MYSM1 1.24 chromatin organization,
Spen Family Transcriptional Repressor SPEN 1.23 regulation of transcription from RNA polymerase II promoter, Notch signaling, negative regulation of transcription,
Zinc Finger E-Box Binding Homeobox 1 ZEB1 1.43 negative regulation of transcription from RNA polymerase II promoter, zinc ion binding, Positively regulates neuronal differentiation. Neuronal deveropment
Bone Morphogenetic Protein 5 BMP5 1.33 Hedgehog signaling pathway, TGF-beta signaling pathway,
Bone morphogenetic protein receptor type 2 BMPR2 1.28 BMP signaling
RAR Related Orphan Receptor A RORA 1.27 neuron differentiation, cell differentiation in hindbrain,
SMAD Family Member 5 SMAD5 1.22 BMP signaling
Neurobeachin NBEA 1.22 neuronal post-Golgi membrane traffic
Leucine Rich Repeat Transmembrane Neuronal 1 LRRTM1 1.22 neuron projection, axon, growth cone, exhibits strong synaptogenic activity,
Neuronal Differentiation 1 NEUROD1 1.20 neuron differentiation, cell cycle arrest