Fig. 2. Incorporation of click chemistry into citrate-based materials.

(A) Synthesis of clickable POC pre-polymers POC-N₃ and POC-Alkyne. (B) POC-click polymer network generated by mixing POC-N₃ and POC-Alkyne pre-polymers via synchronous binary cross-linking mechanism (thermal click reaction and esterification) and further bioactive moieties incorporation via strainpromoted azide-alkyne cycloaddition (SPAAC). The mechanical properties, tensile strength, Young’s modulus (C), and suture retention strengths (D) of POC, POC-click and CUPE tubular biphasic scaffolds (Panel C and D reproduced with permission from figure 2 of Reference 33).