Figure 3. APRIL selectively induces immune regulatory and suppressive genes in Treg but not Tcon.
Treg (left) and Tcon (right) cells freshly purified from the same individual (n=5) were incubated with APRIL, in the presence of antagonistic anti-APRIL mAbs (A1, A2). cnt, control media. Expression levels of indicated genes by qRT-PCR were normalized by internal controls GAPDH and 18S. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.