Figure 7. MM BM-derived regulatory B cells express TACI to specifically mediate APRIL-induced IL-10 production.
BM mononuclear cells from MM patients were incubated with APRIL in the presence of anti-APRIL mAb for 7d. Shown in (a) are dot plots of a representative experiment. (b) Percentages of IL-10+ Bregs (CD19+CD24highCD38high) was determined using flow cytometry analysis from 4 samples. * p < 0.02, ** p < 0.01, *** p < 0.0005, **** p < 0.0001.