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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: Leukemia. 2018 Aug 22;33(2):426–438. doi: 10.1038/s41375-018-0242-6

Figure 7. MM BM-derived regulatory B cells express TACI to specifically mediate APRIL-induced IL-10 production.

Figure 7.

BM mononuclear cells from MM patients were incubated with APRIL in the presence of anti-APRIL mAb for 7d. Shown in (a) are dot plots of a representative experiment. (b) Percentages of IL-10+ Bregs (CD19+CD24highCD38high) was determined using flow cytometry analysis from 4 samples. * p < 0.02, ** p < 0.01, *** p < 0.0005, **** p < 0.0001.

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