Table 1:
Sensitivity Testing for Robustness to Death of Participants during Follow-up: Associations of Pre-Frailty with Post-Discharge Count of Disability among Older Survivors of Critical Illness
| Count Outcome: Post-Discharge Functional Disability (0 – 13)a | |||
|---|---|---|---|
| Imputation Approach for Follow-up Outcomes Missing From Decedents | Sample Size (person-months) | Indicator of Pre-Frailty (1 ≤ Fried ≤ 2) referent to Fried = 0 | |
| Rate Ratio (95% CI) | p-valueb | ||
| Complete Case | 1433 from 215 persons | 1.28 (1.01 – 1.63) | 0.042 |
| MAR | 1596 from 215 persons | 1.31 (1.04 – 1.64) | 0.020 |
| MNAR (all missing set to 0) | 1596 from 215 persons | 1.36 (1.05 – 1.76) | 0.018 |
| MNAR (all missing set to 7) | 1596 from 215 persons | 1.27 (1.01 – 1.59) | 0.041 |
| MNAR (all missing set to 13) | 1596 from 215 persons | 1.21 (0.94 – 1.56) | 0.134 |
sum of disability in four basic activities of daily living, five instrumental activities of daily living, and four mobility measures
multivariable negative binomial regression with GEE with autoregressive correlation structure and adjustment for age, sex, race, education, body mass index, depressive symptoms, number of chronic conditions, cognitive status, pre-ICU count of disability, ICU length of stay, mechanical ventilation, shock, and number of months since the comprehensive interview
Abbreviations: GEE = generalized estimating equations; MAR = missing at random; MNAR =missing not at random
Reprinted with permission of Elsevier. Copyright © 2018 Elsevier.
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The association of frailty with post-ICU disability, nursing home admission, and mortality. Chest. 2018 Jun;153(6):1378–1386. doi: 10.1016/j.chest.2018.03.007. Epub 2018 Mar 17. PMID: 29559308.