Table 2.
Sensitivity Testing for Robustness to Death of Participants during Followup: Associations of Vision Impairment with Functional Recovery among Older Survivors of Critical Illness
| Datasets Used in Model of Time to Functional Recovery within Six Months of ICU Admission (N=218 in each case) |
Rate of Recovery Among 35 Decedents Censored by Deatha | Multivariable Association between Vision Impairment and Functional Recovery within Six Months | |
|---|---|---|---|
| HR (95% CI) | p-valueb | ||
| All Person-Admissions with 35 decedents not imputed (complete case results) | 0% | Cause Specific 0.59 (0.37, 0.95) | 0.031 |
| Fine and Gray 0.64 (0.42, 0.98)c | 0.038c | ||
| MAR Imputations of time to recovery and its occurrence | 41% | 0.61 (0.38, 0.96) | 0.032 |
| MNAR where all 35 decedents set to non-recovery with censoring at six months | 0% | 0.58 (0.37, 0.90) | 0.015 |
| MNAR Imputations of recovery (shift=0.8 and sigma=0.2) and MAR imputation of time to recovery | 55% | 0.61 (0.39, 0.97) | 0.038 |
| MNAR Imputations of recovery (shift=1.5 and sigma=0.5) and MAR imputation of time to recovery | 63% | 0.63 (0.39, 1.00) | 0.049 |
| MNAR Imputations of recovery (shift=2.0 and sigma=0.5) and MAR imputation of time to recovery | 69% | 0.62 (0.38, 1.01) | 0.054 |
| MNAR where all 35 decedents set to recovery at time of death | 100% | 0.72 (0.48, 1.08) | 0.114 |
among 183 not censored by death, in all cases, fixed rate of recovery (62%)
Cox regression with random intercept and adjustment for age, sex, race, increase in disability from pre-ICU, hearing impairment, body mass index, and functional self-efficacy calculated over ten imputations.
Fine and Gray hazard of sub-distribution from single imputation.
Abbreviations: HR = hazard ratio; CI = confidence interval; ICU=Intensive Care Unit;
MV = multivariable, MAR = missing at random, MNAR = missing not at random
Reprinted with permission of the American Thoracic Society. Copyright © 2018 American Thoracic Society.
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors associated with functional recovery among older ICU survivors. American Journal of Respiratory and Critical Care Medicine 2016, Aug 1:194(3):299–307. Doi: 10.1164/rccm.201506–1256OC. PMID:26840348
The American Journal of Respiratory and Critical Care Medicine is an official journal of the American Thoracic Society.