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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Nat Med. 2019 Jan 21;25(2):277–283. doi: 10.1038/s41591-018-0304-3

Extended Data Fig. 2 |. No difference in baseline CSF and serum NfL levels among APP, PSEN1, and PSEN2 mutation carriers.

Extended Data Fig. 2 |

a, Two-tailed pairwise Student’s t-test comparisons of CSF NfL levels of carriers of a mutation in APP (n = 14), PSEN1 (n = 82), or PSEN2 (n = 11). b, Same analysis, using a two-tailed pairwise Student’s t-test for the serum NfL of carriers of a mutation in APP (n = 39), PSEN1 (n = 185), or PSEN2 (n = 19). No differences in log(CSF NfL) or log(serum NfL) were found between the groups (F(2, 104)= 1.8108, P = 0.1686 and F(2, 240)= 1.9205, P = 0.1488, respectively). Similarly, no differences were found by two-tailed pairwise Student’s t-test when age and disease status (presymptomatic, symptomatic) were treated as covariates. The boxes map to the median, 25th and 75th quintiles, and the whiskers extend to the 1.5 × IQR.