Mean magnetic susceptibility (A), R2* (B) and corrected volume (C) in each ROI of the control, >8yr pre-HD, <8yr pre-HD, and early HD groups. The boxes shaded with lighter colors denote the 95% CI and the darker colors denote ±1 SD. The red lines represent the mean. *, ** and *** indicate significant differences with p < 0.05, p < 0.01 and p < 0.001 controlling for age and gender. Correlation analysis of magnetic susceptibility (D) and R2* (E) with corrected structure volumes while controlling for age and gender in all HD patients. CN: caudate nucleus, PT: putamen, GP: globus pallidus, HIPP: hippocampus, SN: substantia nigra, RN: red nucleus.