TABLE 1:

Demographic parameters and clinical assessment scores of controls and CAG-expanded HTT allele carriers (HD group

	Controls	All HD	> 8yr pre-HD	< 8yr pre-HD	Early HD
Number	16	24	9	6	9
Sex (male/female)	8:8	13:11	6:3	1:5	6:3
Age (yr)	44.8 ± 15.8	42.5 ± 12.9	34.4 ± 10.9	41.7 ± 11.5	50.8 ± 10.9
Education (yr)	16.1 ± 2.0	15.3 ± 2.2	14.7 ± 1.9	16.8 ± 2.6	14.9 ± 2.0
CAG length	--	43.8 ± 4.3	41.8 ± 2.8	44.0 ± 4.2	45.6 ± 5.1
CAPs score	--	0.9 ± 0.4	0.6 ± 0.2	1.0 ± 0.1	1.3 ± 0.2
UHDRS Motor score	--	15.9 ± 17.4	4.3 ± 4.3	14.2 ± 11.8	28.6 ± 20.8
UHDRS Function score	24.9 ± 0.5	23.3 ± 3.5*	25.0 ± 0.0	23.0 ± 4.0	21.7 ± 4.4*
UHDRS Behavior score	3.5 ± 4.7	9.6 ± 11.2*	7.0 ± 5.7	7.7 ± 4.5	13.6 ± 16.9
Total functional capacity	13 ± 0.0	11.5 ± 3.0*	12.9 ± 0.3	11.0 ± 3.3	10.3 ± 3.9
Montreal Cognitive Assessment	29.6 s 0.7	28.2 ± 2.8*	29.6 ± 0.2	28.2 ± 2.7	26.8 ± 3.6*
Symbol-Digit Modalities Test score	--	51.5 ± 22.1	58.1 ± 16.9	54.0 ± 19.8	42.1 ± 27.7
Verbal Fluency Test score	47.4 s 12.8	41.3 ± 17.4	50.1 ± 11.8	42.5 ± 16.9	30.5 ± 18.7*

NOTES: CAPs score = CAG-age product scaled score; UHDRS = Unified Huntington’s Disease Rating Scale; Data are presented as means ± standard deviation

^*Significant difference as compared to controls with p < 0.05.