Table 1.
Characteristics of entire sample and of MCI subgroups
| Characteristic at “baseline” * | Total N |
All participants N=1603 |
Consistently normal participants N=881 |
Reverters from MCI to normal N=252 |
Stable MCI N=384 |
Progressors from MCI to dementia N=86 |
Overall Kruskal-Wallis, chi-square or Fisher’s exact test: P value |
|
|---|---|---|---|---|---|---|---|---|
| Age | Mean (SD) | 1603 | 77.7 (7.6) | 75.2 (7.0) | 77.5 (7.0) | 82.3 (6.9) | 83.6 (5.7) | 0.0001 |
| Sex | % female | 1603 | 62.0 | 62.1 | 58.7 | 64.1 | 61.6 | 0.605 |
| Education | % < HS | 1603 | 13.0 | 8.3 | 12.7 | 20.3 | 29.1 | |
| % =HS | 44.8 | 44.6 | 45.2 | 47.40 | 33.7 | <0.001 | ||
| % >HS | 42.2 | 47.1 | 42.1 | 32.3 | 37.2 | |||
| Any subjective memory concerns (SMC) | % >0 | 1600 | 70.8 | 51.4 | 96.0 | 94.5 | 93.0 | <0.001 |
| Number of SMC | Median (IQR) | 1600 | 2 (4) | 1 (2) | 4 (2) | 4 (3) | 5 (4) | 0.0001 |
| Self-rated health | % Poor + fair | 1603 | 17.1 | 11.8 | 23.4 | 24.2 | 20.9 | <0.001 |
| Any IADL impairments | % >0 | 1603 | 19.6 | 8.2 | 21.0 | 38.3 | 48. | <0.001 |
| Depressive symptoms (>3) | % >3 | 1603 | 8.1 | 4.7 | 12.3 | 11.5 | 15.1 | <0.001 |
| APOE*4 genotype | % E*4 | 1478 | 20.9 | 19.2 | 21.4 | 21.9 | 34.2 | 0.1 |
| Systolic blood pressure (SBP) | % >130 | 1603 | 51.1 | 51.8 | 48.0 | 51.0 | 53.5 | 0.727 |
| Diastolic blood pressure (DBP) | % >70 | 1603 | 59.6 | 64.7 | 61.9 | 49.0 | 47.7 | <0.001 |
| H/o Stroke/TIA | % yes | 1603 | 11.8 | 8.5 | 12.3 | 18.2 | 22.1 | <0.001 |
| H/o Heart attack | % yes | 1603 | 36.6 | 35.3 | 39.3 | 37.8 | 36.1 | 0.646 |
| H/o Diabetes | % yes | 1603 | 22.2 | 20.4 | 20.2 | 27.3 | 23.3 | 0.044 |
| Current Smoking | % current | 1603 | 6.9 | 8.5 | 6.4 | 3.4 | 7.0 | 0.011 |
| Current Alcohol consumption | % current | 1603 | 80.4 | 88.3 | 79.4 | 66.7 | 62.8 | <0.001 |
| Number of prescription medications | Median (IQR) | 1603 | 4 (4) | 3 (4) | 5 (4) | 5 (5) | 4 (3) | 0.0001 |
| Exercise | % any | 1603 | 59.6 | 63.2 | 56.8 | 55.5 | 48.8 | 0.006 |
*
Baseline for Stable Normal group is study entry (assessment 1). Baseline for MCI groups is the “index visit” at which the participant was first classified as MCI (CDR=0.5)
SMC: Subjective Memory Concerns
IADL: Instrumental Activities of Daily Living
Mean and SD, or median and interquartile range, were compared for continuous variables, and percentages for categorical variables. To detect overall group differences, Kruskal-Wallis rank tests were performed for continuous predictors when the assumptions for one-way ANOVA were not met. Chi-square tests were performed for categorical predictors, and Fisher’s Exact Tests were conducted when sample size was small.