Table 3.
Reverter vs. Consistently Normal | Stable MCI vs. Consistently Normal | Progressor vs. Consistently Normal | |||||||
---|---|---|---|---|---|---|---|---|---|
RRR | SE | p-value | RRR | SE | p-value | RRR | SE | p-value | |
Cognitive Domain Composite Scores | |||||||||
Attention† | 0.657† | 0.069 | <0.001 | 0.563† | 0.056 | <0.001 | 0.375† | 0.065 | <0.001 |
Executive | 0.576 | 0.067 | <0.001 | 0.344 | 0.038 | <0.001 | 0.236 | 0.04 | <0.001 |
Language | 0.587 | 0.071 | <0.001 | 0.274 | 0.031 | <0.001 | 0.200 | 0.031 | <0.001 |
Memory | 0.558 | 0.065 | <0.001 | 0.236 | 0.027 | <0.001 | 0.1 | 0.019 | <0.001 |
Visuospatial | 0.783 | 0.064 | 0.004 | 0.543 | 0.048 | <0.001 | 0.421 | 0.068 | <0.001 |
% with Cognitive Impairment by Domain | |||||||||
Attention | 3.309 | 1.885 | 0.036 | 3.713 | 1.874 | 0.009 | 7.954 | 4.565 | <0.001 |
Executive | 13.243 | 10.465 | 0.001 | 19.052 | 14.339 | <0.001 | 45.407 | 35.655 | <0.001 |
Language | 2.946 | 1.297 | 0.014 | 6.049 | 2.193 | <0.001 | 12.167 | 5.199 | <0.001 |
Memory | 2.215 | 2.033 | 0.386 | 2.619 | 0.744 | 0.001 | 5.473 | 2.043 | <0.001 |
Visuospatial | 1.459 | 0.518 | 0.288 | 2.074 | 0.591 | 0.001 | 4.885 | 1.774 | <0.001 |
Baseline for Stable Normal group is study entry (assessment 1). Baseline for MCI groups is the assessment at which the participant was first classified as MCI (CDR=0.5)
For example, a one-unit change in the composite attention domain score multiplied the risk of reversion by 0.657, of stable MCI by 0.563, and of progression by 0.375, compared to remaining stably normal.