Table 5.

Lesion areas as determined by histology, DCE NPAs, 55°C isotherms, and thermal dose

Treatment	Canine	Histological lesion area (cm2)	Non‐perfused area (cm2)	55°C isotherm area (cm2)	240 CEM43 area (cm2)
Saline	2	0.48	0.41	0.85	1.27
	4	0.20	0.29	0.34	0.60
	5	0.35	0.27	1.03	1.64
	6	0.32	0.21	0.01	0.15
sUPEs only	2	1.05	1.04	1.48	1.97
	4	0.15	0.13	0.22	0.49
	5	0.23	0.36	0.30	0.37
	6	0.90	0.84	1.00	1.05
sUPEs + Optison	2	0.93	1.06	1.66	1.89
	4	0.03	0.03	0.00	0.04
	5	0.48	0.64	0.88	1.05
	6	0.69	1.11	1.28	1.48

Only canines receiving all three treatments are included.