Table 2b-.

Prediction model performance evaluated using different optimization strategies.

Optimization	Accuracy	Sensitivity	Specificity	PPV	NPV
Max(sen + spec)a	79%	71%	82%	60%	89%
Max(PPV + NPV)b	79%	24%	99%	95%	79%
Equal probabilityc	80%	48%	92%	68%	83%
Max(PPV)d	78%	19%	100%	97%	78%
Max(NPV)e	50%	93%	35%	36%	95%

^aMaximizing sensitivity and specificity (equally weighted), Youden’s J statistic

^bMaximizing PPV and NPV (equally weighted)

^cEqual probability of low/high risk (50% threshold)

^dMaximizing PPV

^eMaximizing NPV

Sen = Sensitivity; Spec = Specificity; PPV = Positive predictive value; NPV = Negative predictive value