Table 3.
PRS logistic and Cox regression top results
| Logistic | ||||||||
|---|---|---|---|---|---|---|---|---|
|
Cancer Type |
Top PRS | OR |
Lower CI |
Upper CI |
Padj | Pbon |
N cases |
N |
| NMSC | BCC pT1×10−5 | 1.61 | 1.22 | 2.12 | 0.0022 | 0.03 | 165 | 438 |
| SCC | SCC pT1×10−9 | 1.97 | 1.32 | 2.93 | 0.0023 | 0.03 | 100 | 283 |
| BCC | SCC pT1×10−6 | 3.03 | 1.78 | 5.16 | 0.0001 | 0.0016 | 60 | 243 |
| Cox | ||||||||
|
Cancer Type |
Top PRS | HR |
Lower CI |
Upper CI |
Padj | Pbon |
N events |
N |
| NMSC | SCC_pT1×10−5 | 1.41 | 1.24 | 1.61 | 9.39E- 07 |
1.29E-05 | 239 | 889 |
| SCC | SCC_pT1×10−6 | 1.48 | 1.25 | 1.74 | 9.35E- 06 |
0.0001 | 150 | 593 |
| BCC | SCC_pT1×10−6 | 1.67 | 1.35 | 2.06 | 5.5E-06 | 7.02E-05 | 106 | 549 |
Meta-analysis results for logistic regression and Cox regression. Models were adjusted for age at time of transplant, era of transplant (pre-2000 vs 2000 onwards), recruitment site and the first 8 principal components. (NMSC=non-melanoma skin cancer, SCC = squamous cell carcinoma, BCC= basal cell carcinoma, Top PRS = most significant polygenic risk score associated with given skin cancer in given model. OR = odds ratio, HR= hazards ratio, Lower/Upper CI = lower/upper 95% confidence interval, OR and HR based on 1 standard deviation increase in normalized PRS, Padj=approximate adjusted p value, Pbon=Bonferroni corrected p value (corrected for 36 tests); N = number of individuals tested