Table 4.
PRS logistic and Cox regression top results split by decile
| Logistic Top PRS BCC pT0.00001 |
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|---|---|---|---|---|---|---|
| PRS by decile | OR | Lower CI |
Upper CI |
P | N | N Cases |
| 2nd Decile | 2.48 | 0.68 | 9.02 | 0.17 | 92 | 24 |
| 3rd Decile | 1.61 | 0.49 | 5.28 | 0.43 | 89 | 24 |
| 4th Decile | 2.20 | 0.76 | 6.35 | 0.15 | 94 | 31 |
| 5nd Decile | 3.17 | 0.91 | 11.04 | 0.07 | 101 | 26 |
| 6nd Decile | 1.32 | 0.40 | 4.38 | 0.65 | 91 | 27 |
| 7nd Decile | 4.10 | 1.20 | 13.98 | 0.024 | 91 | 27 |
| 8nd Decile | 6.06 | 1.67 | 21.92 | 0.006 | 96 | 34 |
| 9nd Decile | 4.35 | 1.35 | 13.99 | 0.014 | 96 | 31 |
| 10th Decile (highest) | 5.22 | 1.65 | 16.57 | 0.005 | 89 | 36 |
| Cox Top PRS SCC pT0.00001 |
||||||
| PRS by decile | HR |
Lower CI |
Upper CI |
P | N | N events |
| 2nd Decile | 1.24 | 0.58 | 2.67 | 0.58 | 178 | 34 |
| 3rd Decile | 1.49 | 0.75 | 2.97 | 0.25 | 178 | 39 |
| 4th Decile | 2.09 | 1.00 | 4.35 | 0.049 | 178 | 41 |
| 5th Decile | 2.00 | 0.98 | 4.08 | 0.06 | 177 | 37 |
| 6th Decile | 1.90 | 0.93 | 3.87 | 0.08 | 178 | 42 |
| 7th Decile | 0.99 | 0.47 | 2.12 | 0.99 | 178 | 37 |
| 8th Decile | 1.83 | 0.93 | 3.61 | 0.08 | 178 | 43 |
| 9th Decile | 3.37 | 1.82 | 6.22 | 0.0001 | 178 | 55 |
| 10th Decile (highest) | 3.11 | 1.60 | 6.06 | 0.0008 | 177 | 47 |
Samples in each decile group were compared to those in the first decile group (lowest PRS group). Analyses were adjusted for age, era of transplantation, geographic site and eight PCs. SCC = squamous cell carcinoma, BCC= basal cell carcinoma, Top PRS = most significant polygenic risk score associated with given skin cancer in given model, pT = p-value threshold, OR = odds ratio, HR= hazards ratio, Lower/Upper CI = lower/upper 95% confidence interval, P= p value, N = number of individuals tested, N events = number of skin cancer events observed, N cases = number of individuals with non-melanoma skin cancer.