Table.
Myelodysplastic Syndrome Reported in Patients with Werner Syndrome.
Case | Sex | WS diagnostic confidence | Age at neoplasm diagnosis | Histopathologic diagnosis | Treatment | Clinical result | Reference |
---|---|---|---|---|---|---|---|
1 | M | Possible | 44 | Myelodysplasia/ myelofibrosis |
Etoposide | Died, sepsis | [16] |
2 | M | Possible | 62 | Myelodysplasia | Transfusion | Died, interstitial pneumonitis | [20] |
3 | M | Possible | 61 | RAEB/ myelofibrosis |
Transfusion | Died, pneumonia | [21] |
4 | M | Probable | 63 | RAEB | Transfusion | Died, pneumonia | [22] |
5 | M | Possible | 52 | Myelodysplasia | Unknown | Unknown | [23] |
6 | M | Definite | 29 | RAEB-t | Unknown | Unknown | [24] |
7 | F | Probable | 52 | Myelodysplasia | Watch & wait | Unknown | [25] |
8 | M | Definite | 43 | RAEB-1 | Azacitidine | Died, pneumonia | [26] |
9 | M | Definite | 44 | RAEB-2 | Allo-HSCT | Complete remission | Present case |
WS: Werner syndrome, M: male, F: female, RAEB: refractory anemia with excess of blast, RAEB-t: refractory anemia with excess of blast in transformation, HSCT: hematopoietic stem cell transplantation