Table 1.

Genome editing technologies developed for disease resistance in plants. Artificial zinc finger protein (AZP), in-del (Insertion and deletion), n.d. (not determined), Beet severe curly top virus (BSCTV), Tomato yellow leaf curl China virus (TYLCCNV), Tobacco curly shoot virus (TbCSV), Tomato yellow leaf curl virus (TYLCV), Tomato leaf curl Yunnan virus (TLCYnV), Beet curly top virus (BCTV), Merremia mosaic virus (MeMV), Bean yellow dwarf virus (BeYDV), Cotton leaf curl Kokhran virus (CLCuKoV), Tomato yellow leaf curl Sardinian virus (TYLCSV), Cucumber vein yellowing virus (CVYV), Zucchini yellow mosaic virus (ZYMV), Papaya ring spot mosaic virus W (PRSV-W), Turnip mosaic virus (TuMV), Cassava brown streak virus (CBSV), Cucumber mosaic virus (CMV), replication associated protein (Rep), intergenic region (IR), coat protein (CP), long intergenic region (LIR).

disease	target gene	nuclease	mutation	pathogen	host plant	ref.
				bacteria
rice bacterial blight	OsSWEET14/promoter	TALEN	In-dels	Xanthomonas oryzae pv. oryzae	rice	[25]
rice bacterial blight	OsSWEET13/exon	CRISPR/Cas9	deletions	Xanthomonas oryzae pv. oryzae	rice	[28]
bacterial speck, phytophthora blight, bacterial spot	SlDMR6-1/exon	CRISPR/Cas9	deletions	Pseudomonas syringae pv. tomato, Phytophthora capsici, Xanthomonas spp.	tomato	[34]
citrus canker	CsLOB1/exon	CRISPR/Cas9	In-dels	Xanthomonas citri subsp. citri	citrus	[30]
citrus canker	CsLOB1/promoter	CRISPR/Cas9	deletions	Xanthomonas citri subsp. citri	citrus	[31]
				funguses
powdery mildew	TaMLO/exon	TALEN	In-dels	Blumeria graminis f. sp. tritici	wheat	[38]
powdery mildew	TaEDR1/exon	CRISPR/Cas9	In-dels	Blumeria graminis f. sp. tritici	wheat	[41]
powdery mildew	SlMlo1/exon	CRISPR/Cas9	deletions	Oidium neolycopersici	tomato	[39]
rice blast	OsERF922/exon	CRISPR/Cas9	In-dels	Magnaporthe oryzae	rice	[45]
				viruses
DNA viral disease	replication origin	AZP	n.d.	BSCTV	Arabidopsis	[49]
DNA viral disease	Rep	ZFN	n.d.	TYLCCNV and TbCSV	tobacco	[50]
DNA viral disease	Rep	TALE	n.d.	TbCSV, TYCCNV and TLCYnV	tobacco	[51]
DNA viral disease	IR, CP, RCRII	CRISPR/Cas9	In-dels	TYLCV, BCTV, MeMV	tobacco	[52]
DNA viral disease	LIR, Rep	CRISPR/Cas9	In-dels	BeYDV	tobacco	[54]
DNA viral disease	IR, CP, Rep	CRISPR/Cas9	In-dels	BSCTV	tobacco and Arabidopsis	[55]
DNA viral disease	IR, CP, Rep	CRISPR/Cas9	In-dels	CLCuKoV, TYLCV, TYLCSV, MeMV, BCTV-Logan, BCTV-Worland	tobacco	[53]
RNA viral disease	eIF4E/exon	CRISPR/Cas9	deletions	CVYV, ZYMV, PRSV-W	cucumber	[59]
RNA viral disease	eIF(iso)4E/exon	CRISPR/Cas9	In-dels	TuMV	Arabidopsis	[58]
RNA viral disease	nCBP-1&nCBP-2/exon	CRISPR/Cas9	In-dels	CBSV	cassava	[60]
RNA viral disease	ORF1a, ORFCP and 3'-UTR	CRISPR/Cas9	no cleavage	CMV	tobacco and Arabidopsis	[62]
RNA viral disease	GFP, Hc-Pro and CP	CRISPR/Cas13a	n.d.	TuMV	tobacco	[63]