Table 1.
Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) index for musculoskeletal associated biofilms. FIC index values indicate synergistic (≤0.5), indifferent (0.5-4), or antagonistic (≥4) drug interactions.
| Species / ATCC# | Tobramycin (µg/ml) |
Vancomycin (µg/ml) |
Tobramycin/Vancomycin 1:1 Combination |
|---|---|---|---|
| FIC index | |||
| S. aureus BAA-1556 | 0.25 | 2 | 1.20 |
| S. aureus BAA-1680 | 0.5 | 2 | 1.34 |
| S. aureus 49230 | 0.5 | 2 | 0.81 |
| S. epidermidis 35984 | 16 | 8 | 0.56 |
| S. epidermidis 29886 | 16 | 4 | 0.18 |
| S. epidermidis 700583 | 0.125 | 4 | 1.08 |
| S. epidermidis 14990 | 0.25 | 4 | 1.07 |
| E. faecalis 29212 | 2 | 1 | 1.69 |
| P. aeruginosa 27853 | 0.5 | >64 | 0.89 |
| E. coli 25922 | 2 | >64 | 0.83 |