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. 2019 Feb 1;7:39. doi: 10.3389/fchem.2019.00039

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Copyright © 2019 Wang, Qiu, Liu, Jayawardhana, Yue, Daghlas, Bowers, Datta and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular responses of the metal-organic cage (1) and the nanoparticles of MOCs. (A) A table of the IC₅₀ values of cisplatin, 1, and nMOC determined by MTT assays; (B) Bar graph of IC₅₀ values obtained using a panel of human cancer cell lines; (C) Fluorescence microscopic images obtained for the live/dead cell assay using A2780cis cells treated with cisplatin, 1, or nMOC; (D) Immunoblotting analysis of γH2AX in A2780cis cell line; (E) Annexin V apoptosis assay using A2780cis cells treated with nMOC (left) and cisplatin (right).