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. 2019 Feb 7;9:1534. doi: 10.1038/s41598-018-38209-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LncRNA MIR210HG regulates expression of downstream target genes GADD45B and NFKBIA (A). The relationship between gene significance (a measure of the correlation between a given gene and the opioid variable) and module membership (the relationship between a given gene and the module eigengene) is shown for genes in the firebrick3 module. Overall correlation and significance are noted at the top of the panel. Several genes with highly correlated co-expression in human midbrain, which were subsequently investigated in SKNAS-G cells (panel B), are indicated (B). DAergic SNKAS-G cells were treated for 24 hr with ASO directed against MIR210HG, or a negative control ASO. Selective knockdown of MIR210HG resulted in corresponding, selective reductions in expression of GADD45B and NFKBIA, but not a beta actin negative control (ACTB). The results of two independent experiments were combined (total N = 8 samples per group). *p < 0.0005.