. 2019 Feb 7;9:1605. doi: 10.1038/s41598-019-38842-x

Table 3.

MEDI-579 paratope residues.

VH chain^a	Residue^b
CDR2	Gly 50, Iso 51, Iso 52, Phe 54, Thr 56, Ala 57, Asn 58
CDR3	Glu 95, Arg 97, Trp 99, Leu 100, Glu 100a, Gly 100b
VL chain ^a
CDR1	Tyr 30, His 31, Asn 32*
CDR2	Lys 50
FW3/outer loop	Arg 66*, Ser 67, Gly 68
CDR3	Tyr 91, Ser 92, Asn 93, Tyr 94, Leu 96

Residues within 4.0 Å of PAI-1 are listed and categorised by Kabat definition. Residues involved in H-bonding networks are highlighted in underline. Residues that form salt-bridges with PAI-1 are highlighted in bold. *Indicates residues introduced during affinity maturation.