Table 3.

Multivariate Cox proportional hazard models for predictors of overall survival in cohort 1 patients.

Factors	Univariate survival analysis		Multivariate survival analysis
	HR (95% CI)	P value	HR (95% CI)	P value
c-MYC GCN gain in both SISH and ddPCR (SISH+/ddPCR+)	5.807 (2.072–16.276)	0.001	6.067 (1.912–19.258)	0.002
Venous invasion	5.292 (2.957–9.470)	<0.001	1.476 (0.750–2.904)	NS (0.256)
Differentiation (low grade vs. high grade)	3.619 (1.869–7.008)	<0.001	2.503 (1.212–5.170)	0.013
T stage (1–2 vs. 3–4)	9.051 (1.247–65.675)	0.029	2.395 (0.300–19.139)	NS (0.410)
N stage (0 vs. 1, 2)	5.658 (2.529–12.659)	<0.001	1.770 (0.701–4.469)	NS (0.227)
M stage (0 vs. 1)	14.758 (7.789–27.964)	<0.001	8.882 (4.145–19.031)	<0.001