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. 2019 Feb 7;9:1628. doi: 10.1038/s41598-018-38231-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of different dose-response curves for two cell lines in CCLE post AZD-6244 application with similar AUC values but different responses at higher doses. The complete dose-response profile prediction using Functional Random Forest is able to capture the difference in response behaviors for majority of the doses.