Table 7.

Protein-protein interaction enrichment analysis for top 200 genes picked from RF and FRF using the whole genome statistical background with a minimum interaction score of 0.15.

Drug	Model	#Nodes	#Edges	Expected #edges	Ratio of observed to expected #edges	PPI enrichment p-value
Erlotinib	RF	107	132	127	1.04	0.356
	FRF	105	170	142	1.20	0.013
Nilotinib	RF	102	185	162	1.14	0.044
	FRF	101	173	144	1.20	0.010
PD-0325901	RF	107	191	187	1.02	0.407
	FRF	113	153	139	1.10	0.134
PLX-4720	RF	106	159	147	1.08	0.164
	FRF	111	217	187	1.16	0.018
TAE-684	RF	103	159	141	1.13	0.078
	FRF	106	180	151	1.19	0.011