Fig. 6.

RGM-A in pediatric ICU patients with abdominal compartment syndrome. Plasma samples from 109 ICU children with and without abdominal compartment syndrome (ACS) were collected within 24 h after admission to and at day of discharge from the Pediatric Intensive Care Unit (PICU) of Hannover Medical School (MHH, Germany). a Representative images displaying critical ill children with IAH (conservative therapy management) (left) and ACS (after decompressive laparotomy with the establishment of an open abdomen / laparostoma to reduce intra-abdominal pressure and the associated tissue and organ impairments) (right). Despite surgical decompression, the child from the ACS cohort died of uncontrollable multiple organ failure. b Overview of ICU patient characteristics within the control group (Prism-III-score < 8), critically ill children with IAH (IAP > 10 mmHg) but without ACS and critically ill children meeting the WSACS definitions²⁹ for ACS. c Correlation between RGM-A and clinical parameters of all PICU patients at day of admission enrolled. d Correlation between RGM-A and risk of mortality at day of admission in subgroups. e Correlation between RGM-A at day of admission and discharge and the average infusion rate of the catecholamines Epinephrine, Norepinephrine and Dobutamine. The Spearman’s rank correlation coefficient Rho and the corresponding 95% CI interval are shown. Results are displayed as median ± 95% CI; non-parametric Mann-Whitney test; correlation was tested using Spearman’s rank correlation test; *P < 0.05