Table 2.

HRs^a per 39 mg/dL (1 mmol/L) TC increase according to sex, age, and TC range.

TC range,	Age group,	Men			Women			p value for interaction between sexes
mg/dL (mmol/L)	years	No. of deaths	p-value	HR (95% CI)	No. of deaths	p-value	HR (95% CI)
50–449	All ages	453,959	<0.001	0.90 (0.89–0.90)	239,545	<0.001	0.95 (0.95–0.96)	<0.001
	18–34	16,111	0.098	0.98 (0.97–1.00)	4,580	0.231	1.02 (0.99–1.06)	0.071
	35–44	37,382	<0.001	0.90 (0.89–0.91)	10,540	0.468	0.99 (0.97–1.01)	<0.001
	45–54	67,370	<0.001	0.85 (0.84–0.85)	21,552	<0.001	0.95 (0.93–0.96)	<0.001
	55–64	116,119	<0.001	0.86 (0.86–0.87)	45,787	<0.001	0.92 (0.92–0.93)	<0.001
	65–74	144,609	<0.001	0.92 (0.91–0.92)	88,046	<0.001	0.96 (0.95–0.96)	<0.001
	75–99	72,368	<0.001	0.94 (0.93–0.95)	69,040	<0.001	0.97 (0.96–0.97)	<0.001
50–199	All ages	283,239	<0.001	0.75 (0.74–0.75)	114,022	<0.001	0.81 (0.80–0.82)	<0.001
	18–34	10,889	<0.001	0.87 (0.84–0.90)	3,608	0.009	0.92 (0.87–0.98)	0.079
	35–44	21,936	<0.001	0.70 (0.68–0.72)	7,072	<0.001	0.86 (0.83–0.90)	<0.001
	45–54	38,832	<0.001	0.64 (0.63–0.65)	10,839	<0.001	0.77 (0.74–0.80)	<0.001
	55–64	70,570	<0.001	0.68 (0.67–0.69)	20,274	<0.001	0.72 (0.70–0.74)	<0.001
	65–74	91,938	<0.001	0.80 (0.79–0.81)	39,339	<0.001	0.80 (0.78–0.81)	0.889
	75–99	49,074	<0.001	0.86 (0.85–0.88)	32,890	<0.001	0.87 (0.86–0.89)	0.356
200–449	All ages	170,720	<0.001	1.07 (1.07–1.08)	125,523	<0.001	1.06 (1.05–1.06)	<0.001
	18–34	5,222	<0.001	1.15 (1.10–1.19)	972	0.006	1.14 (1.04–1.26)	0.953
	35–44	15,446	<0.001	1.12 (1.09–1.14)	3,468	<0.001	1.19 (1.14–1.25)	0.017
	45–54	28,538	<0.001	1.08 (1.06–1.09)	10,713	<0.001	1.08 (1.05–1.11)	0.790
	55–64	45,549	<0.001	1.07 (1.05–1.08)	25,513	<0.001	1.06 (1.05–1.08)	0.761
	65–74	52,671	<0.001	1.07 (1.05–1.08)	48,707	<0.001	1.05 (1.04–1.07)	0.143
	75–99	23,294	0.008	1.03 (1.01–1.05)	36,150	<0.001	1.03 (1.02–1.05)	0.535

CI, confidence interval; HR, hazard ratio; TC, total cholesterol.

^aHRs were calculated by Cox models stratified by age (baseline age, years: 18–24, 25–34, 35–44, 45–54, 55–64, 65–74, 75–84, 85–99), after adjustement for age at baseline, sex (if applicable), smoking status, alcohol use, physical activity, known history of heart disease, stroke, or cancer, body mass index, systolic blood pressure, and total cholesterol.

To convert glucose from mg/dL to mmol/L, multiply by 0.02586.