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. 2019 Feb 7;9:1533. doi: 10.1038/s41598-018-38341-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of GC7 treatment on CD3, CD4 and CD8 cells. CD3 (A), CD4 (B) and CD8 (C) cells at inguinal lymph nodes (IGLN), pancreas (PN), peri-pancreatic lymph nodes (PPLN), and spleen (SP) in GC7 treated and nontreated male and female mice (n = 4–6 per group) are shown. CD3 and CD4 cells percentage were lower in the PN of treated mice whereas, CD8 count was significantly higher in the PN of treated mice. Gr indicates group; Gn indicates gender. Statistical significance determined at P < 0.05. Lowercase letters (a–c) identify significant differences among the groups. Means with different superscript (* or #) have an approaching difference (P = 0.06 to P < 0.1) among the groups or genders.