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. 2019 Feb 7;9:1633. doi: 10.1038/s41598-018-38208-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view- a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gross motor function in drug-treated SMN∆7 mice. LDN-2014 (20 mg/kg) or vehicle (DMSO) injections were administered by IP daily. (A) Scatter plot representing the individual time-to-right of each treated animal (Untreated, DMSO, LDN-2014). (B) Bar graph showing the average time-to-right of each treatment group from ages of P7 through P21, where “*” represents a significant improvement compared to the control groups. (C) Cohorts expressed as a percentage of animals able to right themselves within 30 second. Data expressed as S.E.M.