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. 2019 Feb 7;9:1541. doi: 10.1038/s41598-018-38379-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Failure of optic fissure fusion in ntn1a morphant zebrafish embryos. Expression levels (TPM, transcripts per million) of ntn1a candidate DEG showing temporal expression at 32,48 and 56 hours post fertilization (hpf) (A). (B) Wholemount and ocular morphology of 56 hpf wildtype (wt) and ntn1a morphant embryos, showing loss of ntn1a results in an ocular coloboma phenotype, scale bar 500 µm. (C) Histological analysis confirming loss of optic fissure fusion in ntn1a morphants. Scale bar 50 µm.