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. 2019 Feb 7;9:1583. doi: 10.1038/s41598-018-38272-1

Figure 1.

Figure 1

Representative images of tumor-infiltrating lymphocytes (TILs) in pretreatment tumor specimens in HER2-psitive breast cancer patients. (A) Low-grade TILs: a few lymphocytes in stromal tissue surrounding the cancer nests; (B) intermediate-grade TILs; (C) high-grade TILs: numerous lymphocytes are present in stromal tissue adjacent to the cancer nests. (D) Relationship between TILs grade and pathological complete response (pCR) to neoadjuvant chemotherapy with trastuzumab.