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. 2019 Feb 7;9:1587. doi: 10.1038/s41598-018-38182-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibitory effects of 2 and 3 on 11β-HSD2 using rat kidney microsome. [³H] cortisone and each compound were mixed with the rat kidney microsome fraction, and incubated at 37 °C for 30 min. Then, the amount of [³H] cortisol was measured. Data are expressed as mean ± S.E. (n = 4) of the percentage relative to the amount of [³H] cortisol in the mixture without samples. **P < 0.01 and ***P < 0.001 compared with the groups without the samples by Dunnett’s multiple t-test for compounds 2 and 3, and by Student’s t-test for GA.