Figure 2.

Voluntary running improves the expression of an antioxidant enzyme in LCN2-null NSCs. (a) Cellular quantification of the number of Sox2⁺ NSCs that co-express the antioxidant enzyme Gpx4 showed a significant improved antioxidant regulation in running LCN2-null mice (n = 5 mice per group). (b) Representative confocal images of Sox2 and Gpx4 co-labeling at the DG (scale bar, 50 μm). Data from the sedentary animals is the same as described in Ferreira et al.⁹, and are presented as mean ± SEM and were analyzed by two-way ANOVA with Bonferroni’s multiple comparison test. *Denotes differences between sedentary Wt and LCN2-null mice; ^#between sedentary and running LCN2-null mice. ^#p ≤ 0.05, **p ≤ 0.01.