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. 2019 Feb 7;9:1649. doi: 10.1038/s41598-018-38140-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic diagram of the effects of voluntary running in LCN2-null mice hippocampal neurogenesis and behaviour. In LCN2-null DG, voluntary running stimulates the transition of type-1 to type-2 stem cells, increasing cell proliferation and survival, and the generation of newborn mature neurons. These positive effects in the neurogenic process translated into decreased anxiety and improved contextual discriminative behaviours. GCL, granule cell layer; ML, molecular layer; SGZ, subgranular zone.