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. 2019 Feb 7;9:1603. doi: 10.1038/s41598-018-38179-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TGFβ pathway model. (A) Calibration of the TGFβ pathway model on dataset GSE17708 containing A549 lung adenocarcinoma cell line samples stimulated with 5 ng/mL TGFβ1. (B–G) Validation on independent GEO datasets, different cell types. (B) GSE43700, interleukin 10 (IL10) stimulation of peripheral blood mononuclear cells. (C) GSE7568, TGFβ1 (10 ng/ml) stimulation during indicated time periods of primary macrophages differentiated by treatment with dexamethasone; samples from 5 independent donors. (D) GSE6653, immortalized ovarian surface epithelial cells (IOSE) derived from normal ovarian epithelial cells stimulated with TGFβ1 (10 ng/ml) during time periods as indicated. (E) GSE14491, treatment with TGFβ1 (5 ng/ml) of breast cancer cell line MDA-MB-231, transfected with either control (shGFP) or anti-p53 (shp53) short-hairpin RNAs. (F) GSE59771, TGFβ1 treatment of a colon cancer cell line with inducible TGFβ1 R2 (no associated publication). (G) GSE84500, BMP2 treatment of human mesenchymal stem cells for 1, 2, 3 or 7 days in the presence or absence of TGFβ1 (2 ng/ml). The activity score is calculated as log2odds. Two-sided Wilcoxon signed-rank statistical tests were performed; p-values are indicated in the figures.