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Schematic diagram of the effects and the underlying mechanisms of circRNAs. Mature circRNAs, such as the circ_MTO1, circ_TCF25, circ_MYLK, circ_001569, circ_ciRs-7, circ_ITCH and circ_13958, are released from the nucleus and can function as sponges for the indicated miRNAs, which regulate the respective target genes to promote or inhibit tumor proliferation and metastasis. Standard-shaped arrow, stimulation; T-shaped arrow, inhibition.
