Table 3.
Median regression analyses between plasma Ang-1, Ang-2, and Ang-2/Ang-1 ratio and clinical outcome measures among children with septic shock
| Biomarker | ICU LOS in days (95%CI) p-value |
Vasoactive hrs: (95% CI) p-value |
Max 12hrs VIS: (95% CI) p-value |
Max PELOD 24hrs (95% CI) p-value |
PRISM-III: (95% CI) p-value |
|---|---|---|---|---|---|
| Ang1 | (0.00,0.00) p=0.60 |
0.00 (0.00, 0.00) P=0.57 |
0.00 (0.00, 0.00) p=0.72 |
0.00 (0.00, 0.00) p=1.00 |
0.00 (0.00, 0.00) p=0.26 |
| Ang-2 | (0.00,0.00) p=0.73 |
0.00 (0.00, 0.00) P=0.46 |
0.00 (0.00, 0.00) p=0.07 |
0.00 (0.00, 0.00) p=1.00 |
0.00 (0.00, 0.00) P=0.05 |
| Ang-2/Ang-1 | 0.14 (0.02,0.26) p=0.02 |
0.00 (-0.29, 2.01) P=0.14 |
0.63 (0.15, 1.11) p=0.01 |
0.00 (0.00, 0.00) p=1.00 |
0.35 (0.18,0.52) p<0.0009 |
Ang = Angiopoietin, CI = confidence interval, hrs = hour, ICU LOS = Intensive Care Unit length of stay, PELOD = Pediatric Logistic Organ Dysfunction score, PRISM-III = Pediatric RISk of Mortality-III score, VIS = vasoactive inotrope score