Figure 1.

Blue LED irradiation enhanced ATO induced cell growth suppressive effect in OS cells. (A) U-2 OS cells were treated with ATO at the concentration of 0 μM, 0.1 μM, 0.3 μM, 1.0 μM, 3.0 μM or 10.0 μM for 24 hrs respectively. Representative images were taken under a microscope (magnification ×4) after ATO treatment. (B) The histogram shows the changes of the cell mortality rates. N=3. (C) U-2 OS cells were irradiated with blue LED at the density of 100 mW/cm² for 180 J/cm² in the presence or absence of ATO at the concentration of 0.3 μM or treated with ATO alone. Representative images were taken under a microscope (magnification ×4). (D) The histogram shows the change of the cell mortality rates. N=5. Bar: 100 μm. Data are expressed as the mean ± SEM. ***P < 0.001.