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RA induces apoptosis in drug-sensitive and drug-resistant human OS cells. HOS, KHOSR, U2OS, and U2OSR OS cells were treated with vehicle or the indicated concentration of RA for 48 h. (A) The apoptosis index was determined by flow cytometry with Annexin V-FITC and PI staining. (B) Expression levels of cleaved PARP, Bax, Bcl-2 and Bcl-xl were determined by immunoblotting. *P<0.05, ** P<0.01 compared with vehicle control.
