Figure 2.

The pathogenesis of NAFLD. Peripheral insulin resistance (IR) promotes increased production of free fatty acids (FFA) direct in the liver, resulting in an imbalance between oxidation/divestiture and uptake/synthesis of FFA, and then steatosis liver. The fabric fat secretes adipokines such as leptin, able to adjust the adipocyte metabolism and numerous insulin-mediated processes. Adiponectin plays a role in anti-inflammatory and anti-steatotic; its secretion It is in part regulated by TNF-α under the control of NF-kB.