Table 4.
Association between SNPs of candidate genes and patients with CP in the study cohort
| Gene | SNP ID | Group | HWE | Genotypic analysis | P-value | ||
|---|---|---|---|---|---|---|---|
| pp | pq | ||||||
| IL-10 | rs3024496 | EN | 0.122 | 68 (0.64) | 33 (0.31) | 5 (0.05) | 0.886 |
| CP | 67 (0.65) | 29 (0.28) | 7 (0.07) | ||||
| C/T | |||||||
| IL-10 | rs1800872 | EN | 0.151 | 37 (0.35) | 44 (0.42) | 25 (0.23) | 0.415 |
| A/C | CP | 29 (0.28) | 48 (0.47) | 26 (0.25) | |||
| IL-10RA | rs3135932 | EN | 0.399 | 77 (0.73) | 24 (0.23) | 5 (0.05) | 0.692 |
| A/G | CP | 76 (0.74) | 24 (0.23) | 3 (0.03) | |||
| IL-10RB | rs2834167 | EN | 0.012 | 46 (0.43) | 49 (0.46) | 11 (0.10) | 0.131 |
| A/G | CP | 33 (0.32) | 57 (0.55) | 13 (0.13) | |||
| PD-1 | rs2227982 | EN | 0.488 | 93 (0.88) | 11 (0.10) | 2 (0.02) | 0.939 |
| C/T | CP | 89 (0.86) | 13 (0.13) | 1 (0.01) | |||
| PD-1 | rs10204525 | EN | 0.115 | 76 (0.72) | 28 (0.26) | 2 (0.02) | 0.296 |
| A/G | CP | 68 (0.66) | 31 (0.30) | 4 (0.04) | |||
| PD-L1 | rs4143815 | EN | 0.117 | 77 (0.73) | 26 (0.24) | 3 (0.03) | 0.779 |
| C/G | CP | 78 (0.76) | 21 (0.20) | 4 (0.04) | |||
| PD-L2 | rs7854413 | EN | < 0.001 | 65 (0.61) | 36 (0.34) | 5 (0.05) | 0.037 |
| C/T | CP | 52 (0.50) | 38 (0.37) | 13 (0.13) | |||
CP = chronic pathology; EN = endemic normal; HWE = Hardy–Weinberg equilibrium; SNP = single-nucleotide polymorphism. Bold values represent statistic significance between the EN individuals and CP patients for IL-10RB and PD-L2 SNPs. Genotype and allelic frequencies for IL-10 and PD-1 pathway gene polymorphisms among chronic pathology and control groups were studied using the HWE and association between the SNP and CP was determined.