Table 6.
Multivariate logistic regression analysis including SNP, age, and gender
| SNP | Age | Gender | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | SNP ID | Genotype | Co-dominant analysis | Adjusted odds ratio | 95% confidence interval | P-value | P-value | P-value |
| IL-10 | rs3024496 | CC | CT or TT | 1.970 | 0.550–7.055 | 0.297 | < 0.001 | 0.216 |
| IL-10 | rs1800872 | CC | CA or AA | 0.753 | 0.398–1.422 | 0.381 | < 0.001 | 0.217 |
| IL-10RA | rs3135932 | GG | GA or AA | 0.541 | 0.110–2.661 | 0.450 | < 0.001 | 0.209 |
| IL-10RB | rs2834167 | AA | AG or GG | 0.699 | 0.379–1.289 | 0.252 | < 0.001 | 0.194 |
| PD-1 | rs2227982 | TT | CT or CC | 0.268 | 0.023–3.169 | 0.296 | < 0.001 | 0.173 |
| PD-1 | rs10204525 | AA | AG or GG | 1.813 | 0.302–10.890 | 0.515 | < 0.001 | 0.221 |
| PD-L1 | rs4143815 | CC | CG or GG | 0.802 | 0.398–1.614 | 0.536 | < 0.001 | 0.220 |
| PD-L2 | rs7854413 | CC | CT or TT | 2.942 | 0.957–9.046 | 0.060 | < 0.001 | 0.154 |
SNP = single-nucleotide polymorphism. Bold values represent the influence of a PD-L2 SNP (CC genotype compared with either TT or CT genotypes). Adjusted odds ratio for factor association with chronic pathology using multivariable analysis.