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. 2019 Feb 8;2019(2):CD003032. doi: 10.1002/14651858.CD003032.pub4

3. Adverse effects on lamotrigine: number of participants experiencing each event.

Event Frank 1999 Coppola 2004 Huang 2009 Glauser 2013
Abdominal pain 5      
Headache 2 2   14
Nausea 3     2*
Vomiting       2*
Poor appetite 2     9
Increased appetite   1   10
Diarrhoea       2
Dizziness 3   5 5
Hyperkinesia 2      
Hyperactivity       12
Attention problems       11
Hostility       11
Concentration decreased       9
Personality change       10
Sleep problem       5
Depression       11
Slow process speed       7
Memory problem       8
Apathy       3
Fatigue     1 18
Rash 10 1 2 6
Nervousness   1    
Diplopia   1    

* Nausea, vomiting, or both

Numbers of individuals within each study undertaking lamotrigine: 15 (Frank 1999), 19 (Coppola 2004), 24 (Huang 2009), 146 (Glauser 2013a).