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. 2019 Feb 1;10:48. doi: 10.3389/fphar.2019.00048

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Copyright © 2019 Xiang, Yang, Liu, He, Zhang, Li, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CBS alleviates liver injury and reduces serum bile acid levels in rats with 17α-ethinylestradiol-induced cholestasis. (A) Changes in body weight in each group during the six experimental days. Determination of (B) liver weight, (C) liver/body weight, and (D) serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and (E) total bile acid (BA) levels. (F) Hematoxylin and eosin (H&E) staining was used to investigate hepatic structural changes under non-cholestatic and cholestatic conditions in rats. (G) Immunohistochemistry of CK19 was performed to evaluate proliferation of the bile duct. Data are presented as the mean ± SD (n = 6). Significant differences compared with the non-cholestatic group, ^∗p < 0.05; ^∗∗p < 0.01; compared with the 17α-ethinylestradiol (EE) group, ^#p < 0.05; ^##p < 0.01.