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. 2019 Feb 1;10:48. doi: 10.3389/fphar.2019.00048

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Copyright © 2019 Xiang, Yang, Liu, He, Zhang, Li, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CBS improves intrahepatic bile acid accumulation and composition. (A) Bile was collected for four 15-min periods over 60 min under basal, non-stimulated conditions. The bile flow rate was calculated by gravimetry, assuming the density of the bile of 1.0 g/mL. Representative collection tubes are shown here. (B) Liver total bile acids (BAs). (C) Hepatic individual BAs were assessed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). (D) Analysis of BA composition. Data are presented as the mean ± SD (n = 6). Significant differences when compared with the non-cholestatic group, ^∗p < 0.05; ^∗∗p < 0.01; compared with the 17α-ethinylestradiol (EE) group, ^#p < 0.05; ^##p < 0.01. Abbreviations: MCA, muricholic acid; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; TMCA, tauromuricholic acid; TCA, taurocholic acid; TDCA, taurodeoxycholic acid; TUDCA, tauroursodeoxycholic acid.