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. 2019 Feb 1;10:48. doi: 10.3389/fphar.2019.00048

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Copyright © 2019 Xiang, Yang, Liu, He, Zhang, Li, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CBS reduces bile acid synthesis and promotes bile acid metabolism in cholestatic rats. (A) mRNA expression of bile acid (BA) synthetic enzymes, Cyp7a1 and Cyp8b1, was determined by real-time PCR and normalized to β-actin. (B) Protein expression of hepatic CYP7A1 was determined by Western blot analysis and normalized to β-actin. (C) Representative images of immunohistochemical staining of hepatic CYP7A1. mRNA expression of (D) Cyp3a2, Cyp2b10 and (E) Sult2a1, Bal, and Baat was evaluated by real-time PCR and normalized to β-actin. Data are presented as the mean ± SD (n = 6). Significant differences compared with the non-cholestatic group, ^∗p < 0.05; ^∗∗p < 0.01; compared with the 17α-ethinylestradiol (EE) group, ^#p < 0.05; ^##p < 0.01. N.S., no significance.