Table 1. . List of cytokines referenced in this review article, the T-cell lineage to which they belong, and their role(s) in allergic responses.

Cytokine	T lineage	Elicited response
IFN-γ	Th1	Inhibits IgE synthesis, inhibits Th2 induction, indirectly inhibits eosinophil recruitment to the lung, stimulates IL-12 production by APCs
IL-4	Th2	B-cell isotype switch to IgE production, activates eosinophils and basophils, increases mucus production and secretion
IL-5	Th2	Recruits and activates eosinophils, stimulates basophil differentiation, maturation and activation
IL-6	Th1/Th2	Growth factor for T and B cells, co-factor for IgE synthesis
IL-10	Treg	Suppresses both Th1 and Th2 functions, activates eosinophils and basophils, B cell switch to IgG4 expression
IL-12	Th1	Inhibits IgE synthesis, promotes IFN-γ production
IL-13	Th2	Increases mucus production, B cell switch to IgE production, recruits eosinophils, promotes airway hyperresponsiveness
TNF-α	Th1	May contribute to the pathogenesis of severe allergic asthma
IL-17	Th17	Proinflammatory/increases severity of allergic asthma
IL-22	Th17	Ambiguous role (can suppress and promote asthmatic symptoms)
TSLP	–	Promotes Th2 allergic asthma responses/Th2 memory