Table 2. . Various metabolizing enzymes expressed in anterior segment ocular tissues.

Ocular tissue	Drug-metabolizing enzymes	Ref.
Cornea	CYP-1A/2B/2C/3A/4B1, NADPH reductases, ketone reductases, esterases, arylamine acetyltransferase, glutathione S-transferase. Aldehyde oxidase	[31,79,81–82]
Iris–ciliary bodies	Aldehyde oxidase, glutathione S-transferase, esterase, ketone reductase, CYP-1A/1B1/2B/2C/3A/4B1/39A1	[79,81–82]
Lens	NaDC3, CYP2B, CYP2C, ketone reductase	[81–83]
Conjunctiva	Ketone reductase, aldehyde reductase, CYP-2b/3A/4B1, BCRP1	[81,82]