Figure 7. Enriched Antigen-Presenting Cells in Psoriatic Epidermis and Macrophages in Foreskin.
(A) A fraction of cells from each anatomic site or psoriatic skin belonging to each immune cluster. (B) Log ratio of the observed number of cells from anatomic site or psoriatic skin in cluster to the expected number when sampling cells in the cluster uniformly without replacement. Positive and negative log ratios indicate cluster enrichment and depletion for anatomic site or psoriatic skin. All tissue and cluster associations with solid fill bars are significant (padj < 0.05, Pearson’s chi-square test with Bonferroni adjustment). No trunk cells occurred in the macrophage cluster, so a pseudo-count of 1 cell was added to allow illustration of the log2 fold depletion.