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. 2018 Jun 11;10(6):707–722. doi: 10.2217/epi-2017-0146

Table 3. . Mediation effects for 27 selected top loci in female adipose tissue surviving the two-stage mediation analysis thresholds and with indirect p-value < 0.05.

CpG ID Chr Gen Loc Gene Gene group Re: CGI p(S->Mj) p(Mj->BMI) Indirect 95% CI pindirect Direct 95% CI pdirect R2 Prop. Med
cg04145890 4 1007657 FGFRL1 Body S_Shore 1.62E-04‡ 2.07E-05 1.350 (0.557–2.320) <0.001 1.150 (-0.096–2.300) 0.068 0.366 0.540
cg26750548† 10 88441152 LDB3 Body   0.001 0.001‡ 0.930 (0.281–1.920) <0.001 1.150 (-0.063–2.260) 0.056 0.322 0.447
cg11950105† 17 80050646 FASN Body Island 0.002‡ 0.001 0.682 (0.248–1.350) <0.001 0.790 (-0.269–1.970) 0.134 0.308 0.463
cg21103829 5 140054320 DND1; HARS TSS1500; Body S_Shore 0.001 0.002‡ 1.160 (0.385–2.240) <0.001 1.340 (0.012–2.660) 0.048 0.298 0.464
cg17977470 17 7758854 TMEM88 Body Island 0.004‡ 0.001 0.729 (0.262–1.400) 0.002 1.160 (0.034–2.280) 0.046 0.301 0.386
cg18410680† 17 7758397 TMEM88 1stExon N_Shore 0.002 0.005‡ 0.878 (0.143–1.840) 0.022 1.260 (0.174–2.370) 0.024 0.345 0.411
cg16641055 16 88846292 PIEZO1§ Body S_Shore 0.002 0.003‡ 0.851 (0.275–1.650) 0.002 1.300 (-0.037–2.540) 0.066 0.277 0.396
cg27630153† 16 88845038 PIEZO1§ Body Island 0.001 0.003‡ 0.598 (0.066–1.390) 0.018 0.747 (-0.419–1.910) 0.184 0.304 0.445
cg17274827† 1 94075555 BCAR3 Body   0.001 0.003‡ 1.070 (0.316–2.030) 0.002 1.910 (0.796–2.960) 0.002 0.167 0.359
cg15925478 1 94081080 BCAR3 Body   0.002‡ 3.55E-04 0.600 (0.006–1.350) 0.050 0.766 (-0.133–1.740) 0.110 0.370 0.439
cg02655351 1 3498101 MEGF6 Body N_Shore 0.001‡ 1.96E-04 0.825 (0.249–1.750) 0.004 0.771 (-0.354–1.820) 0.158 0.384 0.517
cg01993576 6 44187674 SLC29A1 5′UTR S_Shore 0.001 0.003‡ 0.764 (0.214–1.490) 0.004 1.030 (-0.373–2.210) 0.134 0.271 0.426
cg07568841 7 30362781 ZNRF2 Body   3.55E-05 0.005‡ 0.986 (0.302–1.890) 0.004 1.010 (-0.729–2.410) 0.254 0.334 0.494
cg12793803 17 62084217 ICAM2 5′UTR;1stExon   0.003‡ 8.82E-04 0.652 (0.188–1.270) 0.004 0.911 (-0.128–1.930) 0.088 0.334 0.417
cg26422861 7 56160737 PHKG1 TSS200   0.002‡ 3.68E-04 1.150 (0.254–2.200) 0.010 1.210 (0.012–2.200) 0.050 0.388 0.487
cg08370546 7 56160770 PHKG1 TSS200   0.002‡ 0.002‡ 0.811 (0.042–1.790) 0.042 1.070 (-0.071–2.180) 0.074 0.385 0.431
cg10780949 15 67418316 SMAD3 Body; 1stExon; 5′UTR   0.002‡ 0.002 0.730 (0.155–1.570) 0.012 1.010 (-0.283–2.060) 0.138 0.316 0.420
cg11199639 8 39172111 ADAM5P TSS200   0.001 0.002‡ 0.975 (0.183–1.940) 0.014 1.200 (0.254–2.310) 0.020 0.344 0.448
cg19659741 8 39172099 ADAM5P TSS200   0.002 0.003‡ 0.567 (0.040–1.480) 0.020 0.941 (0.008–2.080) 0.046 0.341 0.376
cg07387286 8 39172120 ADAM5P TSS200   0.003 0.004‡ 0.699 (-0.024–1.860) 0.066 1.100 (0.042–2.310) 0.038 0.330 0.389
cg11981599 8 11566526 GATA4 Body Island 2.20E-04 2.49E-04‡ 0.888 (0.144–1.820) 0.016 0.674 (-0.505–1.880) 0.226 0.365 0.569
cg25840926† 2 20647987 RHOB 1stExon; 3′UTR Island 3.86E-05 0.005‡ 0.984 (0.155–1.760) 0.018 1.010 (-0.135–2.060) 0.092 0.329 0.493
cg25490145† 17 80358850 C17orf101 Body N_Shelf 3.40E-05 0.001‡ 0.789 (0.144–1.550) 0.020 0.413 (-0.895–1.540) 0.512 0.399 0.656
cg02422603† 13 114890566 RASA3 Body   0.001 0.003‡ 0.900 (0.155–1.820) 0.022 1.110 (-0.192–2.490) 0.084 0.303 0.448
cg02907425 19 4688820 DPP9 Body Island 0.003 0.005‡ 0.874 (0.067–2.040) 0.034 1.390 (0.288–2.430) 0.016 0.380 0.386
cg16582779 14 29237202 FOXG1 1stExon Island 0.001 0.003‡ 0.535 (0.040–1.330) 0.036 0.725 (-0.536–1.870) 0.230 0.389 0.425
cg16145324 6 36020012 MAPK14 Body   0.002‡ 6.38E-04 0.809 (0.270–1.580) 0.002 1.060 (-0.025–1.990) 0.052 0.367 0.433

†Denote sites that were also identified as mediating candidates in prior mediation analyses for socioeconomic status and BMI in the same cohort.

‡Italicized p-values denote the joint significance test p-values, i.e., the maximum p-value from each stage of the two-stage mediation testing analyses.

§PIEZO1 was previously known as FAM38A.

Chr: Chromosome number; Direct: Direct effect; FDR(Mj->BMI): False discovery rate for association of methylation mediator with BMI; Gen Loc: Genetic Location; Indirect: Indirect effect of methylation mediator in association of early life social disadvantage with BMI; pdirect: p-value for direct effect; pindirect: p-value for indirect effect; p(Mj->BMI): p-value for association of methylation mediator with BMI; p(S->Mj): p-value for association of early life social disadvantage with methylation mediator; Prop.Med: Proportion of total association between early life social disadvantage and BMI explained by DNA methylation (calculated indirect effect/[indirect effect + direct effect]; applicable only if indirect and direct effects are in the same direction); R2: Marginal coefficient of variation; Re: CGI: Relationship to canonical CpG island; S: Early life social disadvantage at age 7 years.